Gene description for PKD1
Gene name	polycystic kidney disease 1 (autosomal dominant)
Gene symbol	PKD1
Other names/aliases	PBP Pc-1 TRPP1
Species	Homo sapiens
Database cross references - PKD1
ExoCarta	ExoCarta_5310
Entrez Gene	5310
HGNC	9008
MIM	601313
UniProt	P98161
PKD1 identified in exosomes derived from the following tissue/cell type
Urine	15326289
Urine	19056867

Gene ontology annotations for PKD1

Molecular Function     ion channel binding GO:0044325 IPI     carbohydrate binding GO:0030246 IEA     protein kinase binding GO:0019901 IPI     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IPI     calcium channel activity GO:0005262 ISS Biological Process     mesonephric tubule development GO:0072164 IEP     neural tube development GO:0021915 IEP     kidney development GO:0001822 ISS     mesonephric duct development GO:0072177 IEP     placenta blood vessel development GO:0060674 ISS     peptidyl-serine phosphorylation GO:0018105 ISS     metanephric proximal tubule development GO:0072237 IEP     liver development GO:0001889 IEA     calcium-independent cell-matrix adhesion GO:0007161 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     metanephric collecting duct development GO:0072205 IEP     positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 IDA     organelle organization GO:0006996 TAS     cell-matrix adhesion GO:0007160 TAS     branching morphogenesis of an epithelial tube GO:0048754 IDA     detection of mechanical stimulus GO:0050982 ISS     positive regulation of protein binding GO:0032092 ISS     anatomical structure morphogenesis GO:0009653 TAS     JAK-STAT cascade GO:0007259 ISS     cartilage development GO:0051216 IEP     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     nitrogen compound metabolic process GO:0006807 IEA     protein export from nucleus GO:0006611 ISS     homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 TAS     digestive tract development GO:0048565 IEP     genitalia development GO:0048806 IEP     embryonic placenta development GO:0001892 ISS     metanephric ascending thin limb development GO:0072218 IEP     skin development GO:0043588 IEP     calcium ion transmembrane transport GO:0070588 ISS     response to fluid shear stress GO:0034405 IEA     regulation of proteasomal protein catabolic process GO:0061136 IDA     spinal cord development GO:0021510 IEP     cell cycle arrest GO:0007050 ISS     cytoplasmic sequestering of transcription factor GO:0042994 ISS     in utero embryonic development GO:0001701 ISS     regulation of mitotic spindle organization GO:0060236 IEA     cartilage condensation GO:0001502 IEA     single organismal cell-cell adhesion GO:0016337 IEA     heart development GO:0007507 IEP     lung epithelium development GO:0060428 IEP     metanephric distal tubule morphogenesis GO:0072287 IEP Subcellular Localization     basolateral plasma membrane GO:0016323 IDA     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IEA     integral component of membrane GO:0016021 NAS     polycystin complex GO:0002133 ISS     Golgi membrane GO:0000139 TAS     lateral plasma membrane GO:0016328 IEA     motile primary cilium GO:0031512 ISS     cilium GO:0005929 ISS     primary cilium GO:0072372 ISS     integral component of plasma membrane GO:0005887 TAS     Golgi-associated vesicle membrane GO:0030660 TAS     nucleus GO:0005634 ISS     ciliary membrane GO:0060170 TAS     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 IDA